Donnie: How can you do that?
Frank: I can do anything I want. And so can you.

Kitty Farmer: [to Karen Pomeroy] Excuse me. You need to go back to grad school.

Donnie: Where did you come from?
Frank: Do you believe in time travel?

[being led away in handcuffs by police]
Jim Cunningham: You are a fear prisoner. Yes, you are a product of fear.

Donnie: So, what do I tell the other kids when they ask about you?
Karen Pommeroy: Tell them that everything is gonna be just fine.

Gretchen: My mom had to get a restraining order against my stepdad. He has emotional problems.
Donnie: Oh, I have those too! What kind of emotional problems does your dad have?
Gretchen: He stabbed my mom four times in the chest.
Donnie: Oh.

Karen Pommeroy: It was as though this plan had been with him all his life, pondered through the seasons, now in his fifteenth year crystallized with the pain of puberty.

Donnie: I made a new friend today.
Dr. Lilian Thurman: Real or imaginary?
Donnie: Imaginary.

Frank: 28 days... 6 hours... 42 minutes... 12 seconds. That... is when the world... will end.

Edward Darko: That damn airline better not fuck us on the shingle match.

Donnie: Why do you wear that stupid bunny suit?
Frank: Why are you wearing that stupid man suit?

Kitty Farmer: "No duh" is a product of fear.

Dr. Lilian Thurman: What did Roberta Sparrow say to you?
Donnie: She said, "Every living creature on earth dies alone."

Kitty Farmer: [giving a pep talk to girls about to go on stage] OK ? now, girls. I want you to concentrate. Failure is not an option. And Bethany? If you feel the need to vomit up there, just swallow it.

Gretchen: What if you could go back in time, and take all those hours of pain and darkness and replace them with something better?

Donnie: You are such a fuckass.
Elizabeth: Did you just call me a fuckass? You can go suck a fuck.
Donnie: Oh, please, tell me Elizabeth, how exactly does one suck a fuck?

Dr. Lilian Thurman: The search for God is absurd?
Donnie: It is if everyone dies alone.

Kitty Farmer: Not only am I a teacher, but I am also the mother of a Middlesex child. Therefore, I am the only person here who transcends the parent-teacher bridge.

Dr. Lilian Thurman: If the sky were to suddenly open up, there would be no law, there would be no rule. There would only be you and your memories.

Dr. Lilian Thurman: If this world were to end, there would only be you... and him... and no one else.

Prof. Kenneth Monnitoff: And did you stop and think that maybe infants need darkness? That maybe darkness is part of their natural environment?

Gretchen: Some people are just born with tragedy in their blood.

[before a dance performance]
Kitty Farmer: Okay, now girls... I want you to concentrate. Failure is not an option. And Bethany, if you feel the need to vomit up there... just swallow it.

Karen Pommeroy: This famous linguist once said that of all the phrases in the English language, of all the endless combinations of words in all of history, that Cellar Door is the most beautiful.

Ronald Fisher: [to Cherita Chen] Go Back to China, bitch.

Ronald Fisher: [to Cherita Chen] Hey, porky pig, I hope you get molested.

Ronald Fisher: Someone should write that bitch. [referring to Roberta Sparrow]

Donnie: They say right when they flood the house and they tear it to shreds that... destruction is a form of creation," so the fact that they burn the money is ironic. They just want to see what happens when they tear the world apart. They want to change things.

Karen Pommeroy: The children have to save themselves these days because the parents have no clue.

Cherita Chen: Chut up!

Jim Cunningham: Is that all the gusta you can musta?